澶嶅埗鎴愬姛
  • 鍥炬鑳屾櫙
  • 绾壊鑳屾櫙

绗旇

  • 2019-11-16
    涓哄ぇ浜哄甫鏉ュ舰璞$殑缇婄敓鑲栨晠浜嬫潵鍘 涓哄瀛愬甫鍘诲揩涔愮殑鐢熻倴鍥剧敾鏁呬簨闃呰
    璋堣皥鎬庢牱瀛﹀ソ鏁板_鑻忔闈-涓鐢熸枃搴
zhouwang2

涓婁紶浜庯細2015-06-17

绮変笣閲忥細90

涓浣嶆鍦↖T琛屼笟涓涔犵殑灏忎汉鐗╋紝鎯冲垎浜竴浜涘涔犺祫鏂欑粰鎵鏈変汉

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5-缇熻壊鑳哄惈閲忕殑鍙樺寲鍙婃剰涔夌緹鑹茶兒鍚噺鐨勫彉鍖栧強鎰忎箟缇熻壊鑳哄惈閲忕殑鍙樺寲鍙婃剰涔夌緹鑹茶兒鍚噺鐨勫彉鍖栧強鎰忎箟················································································17鍓嶈█····································································································································································································································································································································································································································17鏉愭枡涓庢柟娉····································································································································································································································································································································································································18缁撴灉····································································································································································································································································································································································································································24璁ㄨ····································································································································································································································································································································································································································31绗簩閮ㄥ垎绗簩閮ㄥ垎绗簩閮ㄥ垎绗簩閮ㄥ垎 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5-缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍦ㄥぇ榧犻鐧岀棝鐨勯晣缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍦ㄥぇ榧犻鐧岀棝鐨勯晣缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍦ㄥぇ榧犻鐧岀棝鐨勯晣缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍦ㄥぇ榧犻鐧岀棝鐨勯晣鐥涙晥搴旇瘎浠风棝鏁堝簲璇勪环鐥涙晥搴旇瘎浠风棝鏁堝簲璇勪环················································································································································································································································································································································35鍓嶈█····································································································································································································································································································································································································································35鏉愭枡涓庢柟娉····································································································································································································································································································································································································36缁撴灉····································································································································································································································································································································································································································41璁ㄨ····································································································································································································································································································································································································································46绗笁閮ㄥ垎绗笁閮ㄥ垎绗笁閮ㄥ垎绗笁閮ㄥ垎 RVMRVMRVMRVM鍖哄尯鍖哄尯5- 5- 5- 5-缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍙備笌澶ч紶楠ㄧ檶鐥涚殑鏈哄埗鐮旂┒缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍙備笌澶ч紶楠ㄧ檶鐥涚殑鏈哄埗鐮旂┒缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍙備笌澶ч紶楠ㄧ檶鐥涚殑鏈哄埗鐮旂┒缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍙備笌澶ч紶楠ㄧ檶鐥涚殑鏈哄埗鐮旂┒································································································································································································································································································································································································································50鍓嶈█····································································································································································································································································································································································································································50鏉愭枡涓庢柟娉····································································································································································································································································································································································································50缁撴灉····································································································································································································································································································································································································································52璁ㄨ····································································································································································································································································································································································································································59绗洓閮ㄥ垎绗洓閮ㄥ垎绗洓閮ㄥ垎绗洓閮ㄥ垎 RVMRVMRVMRVM鍖鸿兌璐ㄧ粏鑳炴椿鍖栧弬涓庡ぇ榧犻鐧岀棝鐨勬満鍒剁爺绌跺尯鑳惰川缁嗚優娲诲寲鍙備笌澶ч紶楠ㄧ檶鐥涚殑鏈哄埗鐮旂┒鍖鸿兌璐ㄧ粏鑳炴椿鍖栧弬涓庡ぇ榧犻鐧岀棝鐨勬満鍒剁爺绌跺尯鑳惰川缁嗚優娲诲寲鍙備笌澶ч紶楠ㄧ檶鐥涚殑鏈哄埗鐮旂┒········································································63 鍗庡崕鍗庡崕 涓腑涓腑 绉戠绉戠 鎶鎶鎶鎶 澶уぇ澶уぇ 瀛﹀瀛﹀ 鍗氬崥鍗氬崥 澹+澹+ 瀛﹀瀛﹀ 浣嶄綅浣嶄綅 璁鸿璁鸿 鏂囨枃鏂囨枃1鍓嶈█····································································································································································································································································································································································································································63鏉愭枡涓庢柟娉····································································································································································································································································································································································································64缁撴灉····································································································································································································································································································································································································································67璁ㄨ····································································································································································································································································································································································································································73缁艰堪缁艰堪缁艰堪缁艰堪········································································································································································································································································································································································································································································80缁艰堪缁艰堪缁艰堪缁艰堪1 1 1 1 楠ㄧ檶鐥涙満鍒朵笌娌荤枟鐮旂┒杩涘睍楠ㄧ檶鐥涙満鍒朵笌娌荤枟鐮旂┒杩涘睍楠ㄧ檶鐥涙満鍒朵笌娌荤枟鐮旂┒杩涘睍楠ㄧ檶鐥涙満鍒朵笌娌荤枟鐮旂┒杩涘睍························································································································································································································································80缁艰堪缁艰堪缁艰堪缁艰堪2 2 2 2 涓嬭鐥涜璋冩帶绯荤粺涓庝笣瑁傚師娲诲寲铔嬬櫧婵閰剁爺绌惰繘灞曚笅琛岀棝瑙夎皟鎺х郴缁熶笌涓濊鍘熸椿鍖栬泲鐧芥縺閰剁爺绌惰繘灞曚笅琛岀棝瑙夎皟鎺х郴缁熶笌涓濊鍘熸椿鍖栬泲鐧芥縺閰剁爺绌惰繘灞曚笅琛岀棝瑙夎皟鎺х郴缁熶笌涓濊鍘熸椿鍖栬泲鐧芥縺閰剁爺绌惰繘灞····················································································92鑷磋阿鑷磋阿鑷磋阿鑷磋阿································································································································································································································································································································································································································································101闄勫綍闄勫綍闄勫綍闄勫綍 鏀昏鏀昏鏀昏鏀昏瀛︿綅瀛︿綅瀛︿綅瀛︿綅鏈熼棿鍙戣〃鏈熼棿鍙戣〃鏈熼棿鍙戣〃鏈熼棿鍙戣〃璁烘枃鐩綍璁烘枃鐩綍璁烘枃鐩綍璁烘枃鐩綍························································································································································································································································102 鍗庡崕鍗庡崕 涓腑涓腑 绉戠绉戠 鎶鎶鎶鎶 澶уぇ澶уぇ 瀛﹀瀛﹀ 鍗氬崥鍗氬崥 澹+澹+ 瀛﹀瀛﹀ 浣嶄綅浣嶄綅 璁鸿璁鸿 鏂囨枃鏂囨枃1涓讳富涓讳富 瑕佽瑕佽 缂╃缉缂╃缉 鐣ョ暐鐣ョ暐 璇嶈瘝璇嶈瘝 琛ㄨ〃琛ㄨ〃绱㈠紩绱㈠紩鑻辨枃缂╁啓鑻辨枃缂╁啓鑻辨枃鍏ㄧО鑻辨枃鍏ㄧО涓枃鍚嶇О涓枃鍚嶇ОBBDNFBrain-derived neurotrophic factor鑴戞簮鎬х缁忚惀鍏诲洜瀛怌CIBPCancer induced bone pain鐧岀棁璇卞鐨勯鐥汥DMSODimethyl sulfoxide浜岀敳鍩轰簹鐮淒LFDorsolateral funiculus鑳屽渚х储GGFAPGlial fibrillary acidicprotein鑳惰川绾ょ淮閰告ц泲鐧紾iANucleus reticularis gigantocellularis parsalpha缃戠姸宸ㄧ粏鑳炴梺鏍α閮℅iVentral nucleus reticularisgigantocellularis缃戠姸宸ㄧ粏鑳炶吂渚ф牳HHRPHorseradish peroxidase杈f牴杩囨哀鍖栫墿閰禜PLCHigh performance liquidchromatography楂樻晥娑茬浉鑹茶氨IIL-1βInterleukin-1β鐧戒粙绱-1βIL-6Interleukin-6鐧戒粙绱-6MMWDMechanical withdrawal duration鏈烘缂╃埅鎸佺画鏃堕棿NNRMNucleus raphe magnus涓紳澶ф牳PPCPApara-chlorophenylalanine瀵规隘鑻熀涓欐皑閰窹WTMechanical paw withdrawal threshold鏈烘缂╃埅闃堝紁38MAPKp38 mitogen-activated protein kinasep38 涓濊鍘熸椿鍖栬泲鐧芥縺閰 鍗庡崕鍗庡崕 涓腑涓腑 绉戠绉戠 鎶鎶鎶鎶 澶уぇ澶уぇ 瀛﹀瀛﹀ 鍗氬崥鍗氬崥 澹+澹+ 瀛﹀瀛﹀ 浣嶄綅浣嶄綅 璁鸿璁鸿 鏂囨枃鏂囨枃2RRVMRostral ventromedial medulla寤堕珦澶寸鑵瑰唴渚у尯SSNLSpinal nerve ligation鑴婄缁忕粨鎵嶵TNF-αTumor necrosis factor α鑲跨槫鍧忔鍥犲瓙-αTPHTryptophan hydroxylase鑹叉皑閰哥緹鍖栭叾5-HT5-hydroxytryptamine5-缇熻壊鑳5,7-DHT5,7-di-hydroxytryptamine5,7-鍙岀緹鑹茶兒 鍗庡崕鍗庡崕 涓腑涓腑 绉戠绉戠 鎶鎶鎶鎶 澶уぇ澶уぇ 瀛﹀瀛﹀ 鍗氬崥鍗氬崥 澹+澹+ 瀛﹀瀛﹀ 浣嶄綅浣嶄綅 璁鸿璁鸿 鏂囨枃鏂囨枃3涓枃鎽樿涓枃鎽樿涓枃鎽樿涓枃鎽樿下载上海快三走势图—官方网址22270.COM鈥旈澏鍚戞姂鍒跺欢楂撲笅琛屾槗鍖栦綔鐢ㄥ湪澶ч紶楠ㄧ檶鐥涗腑鐨勯晣鐥涙晥搴斿強鍏舵満下载上海快三走势图—官方网址22270.COM鈥旈澏鍚戞姂鍒跺欢楂撲笅琛屾槗鍖栦綔鐢ㄥ湪澶ч紶楠ㄧ檶鐥涗腑鐨勯晣鐥涙晥搴斿強鍏舵満下载上海快三走势图—官方网址22270.COM鈥旈澏鍚戞姂鍒跺欢楂撲笅琛屾槗鍖栦綔鐢ㄥ湪澶ч紶楠ㄧ檶鐥涗腑鐨勯晣鐥涙晥搴斿強鍏舵満下载上海快三走势图—官方网址22270.COM鈥旈澏鍚戞姂鍒跺欢楂撲笅琛屾槗鍖栦綔鐢ㄥ湪澶ч紶楠ㄧ檶鐥涗腑鐨勯晣鐥涙晥搴斿強鍏舵満鍒剁爺绌跺埗鐮旂┒鍒剁爺绌跺埗鐮旂┒鍗氬+鐮旂┒鐢熷崥澹敓瀵煎笀鍒樺笇姹熺敯鐜夌 鏁欐巿鍗庝腑绉戞妧澶у鍚屾祹鍖诲闄㈤檮灞炲悓娴庡尰闄㈤夯閱夊鏁欑爺瀹ょ爺绌惰儗鏅爺绌惰儗鏅爺绌惰儗鏅爺绌惰儗鏅檶鐥囧彲琛ㄧ幇鍑虹敓鐞嗗拰蹇冪悊鐨勫绉嶇棁鐘讹紝浣嗘槸鐧岀棁寮曡捣鐨勭柤鐥涘線寰鏄叧閿棁鐘朵箣涓銆下载上海快三走势图—官方网址22270.COM鏈粡娌荤枟鐨勭柤鐥涘彲涓ラ噸褰卞搷鎮h呯殑鐢熸椿璐ㄩ噺锛屽苟鑳藉奖鍝嶇檶鐥囨偅鑰呭娌荤枟鐨勮愬彈绋嬪害浠庤屽奖鍝嶇檶鐥囨偅鑰呯殑棰勫悗銆 闅忕潃鐧岀棁璇婄枟鎶鏈殑杩涙锛 鐧岀棁鎮h呯敓瀛樻椂闂存槑鏄惧欢闀匡紝缂撹В鐧岀棁鎮h呯殑鐤肩棝锛屾彁楂樺叾鐢熸椿璐ㄩ噺鎴愪负绐佸嚭闂銆傛嵁浼拌鐧岀棁鐥涚殑鎮g梾鐜囧湪鏂拌瘖鏂嚭鐨勭檶鐥囨偅鑰呬腑涓 25%锛 鍦ㄧН鏋佹不鐤楃殑鐧岀棁鎮h呬腑涓 33%锛 鑰屽湪鏅氭湡鐧岀棁鎮h呬腑鐧岀棁鐥涚殑鎮g梾鐜囪秴杩 75%銆 鐢变簬鐜版湁涓村簥娌荤枟鐧岀棁鐥涙帾鏂界殑灞闄愭э紝 绾 45%鐨勭檶鐥囨偅鑰呯殑鐤肩棝鏈緱鍒版湁鏁堟帶鍒躲 鍥犺岋紝 瀵圭檶鐥涙満鍒跺拰闀囩棝鎵嬫鐨勫叏闈㈡繁鍏ョ爺绌舵樉寰楀挨涓洪噸瑕併傜檶鐥囧鑷寸殑楠ㄧ棝锛堢畝绉伴鐧岀棝锛夋槸鐧岀棁鎮h呮渶甯歌鐨勪竴绉嶇柤鐥涳紝涔熸槸鑲跨槫鍙戠敓楠ㄨ浆绉绘椂鏈甯歌鐨勭棁鐘朵箣涓銆傚ぇ绾︿笁鍒嗕箣涓鐨勬櫄鏈熺檶鐥囨偅鑰呬細鍙戠敓楠ㄨ浆绉伙紝鑰屽湪涔宠吅鐧屽拰鍓嶅垪鑵虹檶鏅氭湡鎮h呬腑瓒呰繃 70%鐨勬偅鑰呭彂鐢熼杞Щ锛岄杞Щ涔熸槸鐧岀棁鐥涙渶甯歌鐨勫師鍥犮傞鐧岀棝鏄檶鐥囩棝鐨勫吀鍨嬩唬琛紝鍏朵富瑕佽〃鐜版槸锛氭寔缁殑杩涜鎬х殑鑳屾櫙鐥涳紙 Ongoingpain锛 锛岀垎鍙戠棝(Breakthrough pain)銆佺棝瑙夎繃鏁忥紙Hyperalgesia锛夊拰鐥涜瓒呮晱锛圓llodynia锛 銆下载上海快三走势图—官方网址22270.COM鐩墠锛屼复搴婁笂灏氱己涔忔湁鏁堜笖鍓綔鐢ㄥ皬鐨勯鐧岀棝娌荤枟鎺柦锛屾湭鍚堢悊鎺у埗鐨勭柤鐥涗笉浣嗕弗閲嶅奖鍝嶆偅鑰呯敓娲昏川閲忚屼笖鏄捐憲缂╃煭鐢熷瓨鏈燂紝杩欎笌瀵归鐧岀棝鐨勫彂鐥呮満鍒剁己涔忎簡瑙f湁鍏炽 楠ㄧ檶鐥涘彂鐢熸満鍒跺鏉傦紝灞閮ㄦ蹈娑︾殑鑲跨槫缁嗚優銆佺値鐥囩粏鑳炲強鐮/鎴愰缁嗚優绛変骇鐢熺殑鍚勭鐢熺墿瀛︽椿鎬х墿璐紝璇卞澶栧懆鍜屼腑鏋㈢缁忕郴缁熺殑鏁忓寲锛屽叡鍚屽弬涓庝簡楠ㄧ檶鐥涚殑褰㈡垚銆傚苟涓旓紝涓嶅悓绫诲瀷鍜屼笉鍚岄樁娈电殑鑲跨槫浠ュ強涓嶅悓鐨勮偪鐦ょ敓闀块儴浣嶏紝鍧囧彲褰卞搷楠ㄧ檶鐥涚殑鍙戠敓鍙戝睍銆下载上海快三走势图—官方网址22270.COM杩戞潵鐮旂┒琛ㄦ槑锛屼腑鏋㈢缁忎笅琛屾槗鍖栫郴缁熸縺娲诲鎱㈡х柤鐥涚殑缁存寔璧烽噸瑕佷綔鐢ㄣ傚欢楂撳ご绔吂鍐呬晶鍖猴紙rostral ventromedial medulla锛孯VM锛夋槸涓嬭鐥涜璋冩帶绯荤粺鐨勫叧閿粨鏋勩 鍗庡崕鍗庡崕 涓腑涓腑 绉戠绉戠 鎶鎶鎶鎶 澶уぇ澶уぇ 瀛﹀瀛﹀ 鍗氬崥鍗氬崥 澹+澹+ 瀛﹀瀛﹀ 浣嶄綅浣嶄綅 璁鸿璁鸿 鏂囨枃鏂囨枃4RVM 涓昏鐢变腑缂濆ぇ鏍搞佺綉鐘跺法缁嗚優鏍α閮ㄥ拰鑵逛晶缃戠姸宸ㄧ粏鑳炴牳绛夌缁忔牳鍥㈢粍鎴愶紝鏄暣鍚堣剨楂撲笂涓灑鐥涜璋冩帶淇℃伅骞朵笅琛屼紶閫掕嚦鑴婇珦鐨勪腑缁х珯銆俁VM 鍐 50%宸﹀彸鐨勭缁忓厓涓 5-缇熻壊鑳猴紙5-hydroxytryptamine, 5-HT锛夎兘绁炵粡鍏冿紝鍏朵腑鍚湁 5-HT 鐢熺墿鍚堟垚鐨勯檺閫熼叾--鑹叉皑閰哥緹鍖栭叾锛圱ryptophan hydroxylase, TPH锛 锛屽叾浜х敓鐨 5-HT 鍙笅琛屾姇灏勫埌鑴婇珦鑳岃锛屾槸涓嬭璋冩帶绯荤粺鍙備笌鑴婇珦鐤肩棝澶勭悊鐨勪富瑕佺缁忛掕川锛屾潵鑷 RVM 鍖虹殑涓嬭 5-HT瀵硅剨楂撶殑鐥涜淇℃伅澶勭悊璧烽噸瑕佷綔鐢ㄣ傚悓鏃讹紝鍦ㄧ缁忕梾鐞嗘х棝绛夋參鎬х柤鐥涘綋涓紝RVM鍖鸿兌璐ㄧ粏鑳炴椿鍖栧苟鍙備笌鎱㈡х柤鐥涚殑褰㈡垚銆下载上海快三走势图—官方网址22270.COM浣嗘槸锛屽湪楠ㄧ檶鐥涗腑鏉ヨ嚜 RVM 鍖哄苟涓嬭鎶曞皠鍒拌剨楂撹儗瑙掔殑 5-HT 瀵硅剨楂撶棝瑙変俊鎭鐞嗙殑鍏蜂綋浣滅敤浠ュ強楠ㄧ檶鐥涗腑 RVM 鍖鸿兌璐ㄧ粏鑳炴槸鍚﹀弬涓庝笅琛岀棝瑙夎皟鎺у潎灏氫笉娓呮銆備互 RVM 涓烘不鐤楅澏鐐圭爺绌剁檶鐥涙不鐤楃瓥鐣ュ彲涓嶅彈鑲跨槫鐢熼暱銆佽浆绉婚儴浣嶇殑闄愬埗锛岃繕鍙湁鏁堟帶鍒剁檶鐥囨不鐤楀紩璧风殑澶氬彂鎬х缁忕梾鐞嗘х棝銆傚熀浜庢锛 鏈爺绌舵嫙閫氳繃鎺㈣浠 RVM 鍖烘姇灏勫埌鑴婇珦鐨 5-HT 鑳戒笅琛岄氳矾浠ュ強 RVM 鍖鸿兌璐ㄧ粏鑳炲湪楠ㄧ檶鐥涘ぇ榧犵柤鐥涙満鍒朵腑鐨勪綔鐢紝浠ユ湡瀵绘壘鐧岀棝娌荤枟鐨勬柊闈剁偣鍜屾柊鐨勬不鐤楃瓥鐣ャ傜爺绌舵柟娉曚笌缁撴灉鐮旂┒鏂规硶涓庣粨鏋滅爺绌舵柟娉曚笌缁撴灉鐮旂┒鏂规硶涓庣粨鏋1 1 1 1锛庨鐧岀棝澶ч紶鑴婇珦鑳岃锛庨鐧岀棝澶ч紶鑴婇珦鑳岃 5- 5- 5- 5-缇熻壊鑳哄惈閲忕殑鍙樺寲鍙婃剰涔夌緹鑹茶兒鍚噺鐨勫彉鍖栧強鎰忎箟鏂规硶锛氭柟娉曪細瀹為獙涓锛堥鐧岀棝澶ч紶鑴婇珦鑳岃 5-HT 鍚噺涓庡叾鐥涢槇鐨勭浉鍏虫у垎鏋愶級 锛氶泴鎬D 澶ч紶 57 鍙紝闅忔満鍒嗕负 3 缁勶紝姣忕粍 19 鍙1锛夋甯稿鐓х粍锛圢aïve锛 锛氫笉浣滀换浣曞鐞嗭紱2锛夊亣鎵嬫湳缁勶紙Sham锛 锛氫簬鍙充晶鑳涓婃楠ㄩ珦鑵旀敞灏 D-hank’s 娑 10 μl 锛3锛夐鐧岀棝缁勶紙CIBP锛 锛氫簬鍙充晶鑳涓婃楠ㄩ珦鑵旀帴绉 10 μl锛堢害 3×104锛塛alker256 澶ч紶涔宠吅鐧岀粏鑳炴偓娑插埗澶囪儷楠ㄧ檶鐥涙ā鍨嬨下载上海快三走势图—官方网址22270.COM瀹為獙浜岋紙闉樺唴娉ㄥ皠 5-缇熻壊鑳鸿兘閫夋嫨鎬х缁忔瘨绱 5,7-DHT瀵归鐧岀棝澶ч紶鐥涢槇鐨勫奖鍝嶏級 锛氶泴鎬 SD 澶ч紶 56 鍙紝闅忔満鍒嗕负 4 缁勶紝姣忕粍 14 鍙1锛塖ham-Saline 缁勶細鍋囨墜鏈悗绗 10 澶╅灅鍐呯疆绠★紝绗 14 澶╅灅鍐呯粰鐢熺悊鐩愭按锛20μl锛 锛2锛塖ham-5,7-DHT 缁勶細鍋囨墜鏈悗绗 10 澶╅灅鍐呯疆绠★紝绗 14 澶╅灅鍐呯粰 5,7-DHT锛60μg锛 锛3锛塁IBP-Saline 缁勶細閫犳ā鍚庣 10 澶╅灅鍐呯疆绠★紝绗 14 澶╅灅鍐呯粰鐢熺悊鐩愭按锛20μl锛 锛4锛塁IBP-5,7-DHT 缁勶細閫犳ā鍚庣 10 澶╅灅鍐呯疆绠★紝绗 14 澶╅灅鍐呯粰 5,7-DHT锛60μg锛 銆傞噰鐢ㄧ棝瑙夎涓哄鍜岀粍缁囩梾鐞嗗鏂规硶閴村畾妯″瀷鏋勫缓鎴愬姛銆傚垎鍒簬鏈悗绗 7銆14 鍜 21 澶╁彇鍚勭粍澶ч紶鑴婇珦鑳岃缁勭粐锛岄噰鐢ㄩ珮鏁堟恫鐩歌壊璋辨硶妫娴嬭剨楂撹儗瑙掔粍缁囦腑 5-HT 鍚噺锛屽苟涓庣浉 鍗庡崕鍗庡崕 涓腑涓腑 绉戠绉戠 鎶鎶鎶鎶 澶уぇ澶уぇ 瀛﹀瀛﹀ 鍗氬崥鍗氬崥 澹+澹+ 瀛﹀瀛﹀ 浣嶄綅浣嶄綅 璁鸿璁鸿 鏂囨枃鏂囨枃5搴旀椂鐐圭殑鏈烘缂╃埅闃堝煎拰缂╃埅鎸佺画鏃堕棿鍋氬弻鍙橀噺鐩稿叧鍒嗘瀽銆 妫娴嬮灅鍐呯粰浜 5,7-DHT 瀵瑰ぇ榧犵棝瑙夎涓哄鐨勫奖鍝嶃 閲囩敤楂樻晥娑茬浉鑹茶氨鍒嗘瀽鍜屽厤鐤崸鍏夋煋鑹叉娴 5,7-DHT 瀵硅剨楂撹儗瑙 5-缇熻壊鑳鸿兘绁炵粡鐨勬瘉鎹熸晥搴斻傜粨鏋滅粨鏋滐細锛氳偪鐦ょ粏鑳炴帴绉嶅悗 7 ~21 d 澶ч紶鏈烘缂╃埅闃堝兼槑鏄鹃檷浣庯紝缂╃埅鎸佺画鏃堕棿寤堕暱锛岀Щ鍔ㄨ鍙戠棝璇勫垎杩涜鎬у崌楂 锛圥<0.05锛 銆 鍏夐暅涓嬭偪鐦ゆ敞灏勯儴浣嶅彲瑙佸ぇ閲忚偪鐦ょ粏鑳炴蹈娑︼紝楠ㄧ粍缁囩粨鏋勪弗閲嶇牬鍧忥紝 琛ㄦ槑妯″瀷鍒跺鎴愬姛銆 涓庡鐓х粍鐩告瘮锛 楠ㄧ檶鐥涚粍澶ч紶鎺ョ鍚 7 ~21d 鏃舵満姊扮棝闃堥檷浣庯紝鎺ョ鍚 7銆14 鍜 21 d 鏃惰剨楂撹儗瑙 5-HT 鍚噺鍗囬珮锛屼笖 5-HT 鍚噺涓庢満姊扮棝闃堝憟鏄捐憲鐩稿叧 锛圥<0.05锛 銆 闉樺唴娉ㄥ皠 5,7-DHT 鍚庡彲鏄捐憲闄嶄綆鑴婇珦鑳岃涓 5-HT鍚噺锛屽苟鑳芥樉钁楃紦瑙i鐧岀棝澶ч紶鐨勭柤鐥涜涓恒2 2 2 2锛庨澏鍚戞姂鍒讹紟闈跺悜鎶戝埗 RVMRVMRVMRVM 鍖哄尯 5- 5- 5- 5-缇熻壊鑳鸿兘涓嬭鏄撳寲浣滅敤鍦ㄩ鐧岀棝澶ч紶鐨勯晣鐥涙晥搴旇瘎浠风緹鑹茶兒鑳戒笅琛屾槗鍖栦綔鐢ㄥ湪楠ㄧ檶鐥涘ぇ榧犵殑闀囩棝鏁堝簲璇勪环鏂规硶锛氭柟娉曪細闆屾 SD 澶ч紶 108 鍙紝闅忔満鍒嗕负 4 缁勶紝姣忕粍 27 鍙1锛塖ham-Saline 缁勶細 鍋囨墜鏈悗绗 14 澶 RVM 鍖虹粰鐢熺悊鐩愭按锛0.5μl锛 锛2锛塖ham-PCPA 缁勶細鍋囨墜鏈悗绗 14 澶㏑VM鍖虹粰PCPA 锛50μg锛 锛 3锛 CIBP-Saline缁勶細 閫犳ā鍚庣14澶㏑VM鍖虹粰鐢熺悊鐩愭按 锛0.5μl锛 锛4锛塁IBP-PCPA 缁勶細閫犳ā鍚庣 14 澶 RVM 鍖虹粰 PCPA锛50μg锛 銆傛娴嬪悇缁勫ぇ榧犱笉鍚屾椂鐐圭殑鏈烘缂╃埅闃堝笺佺缉鐖寔缁椂闂村拰绉诲姩璇卞彂鐥涜瘎鍒嗐傚厤鐤嵃杩规硶妫娴 RVM 鍖 TPH 鐨勮〃杈俱傞珮鏁堟恫鐩歌壊璋辨硶妫娴 RVM 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