澶嶅埗鎴愬姛
  • 鍥炬鑳屾櫙
  • 绾壊鑳屾櫙

绗旇

  • 2019-11-16
    涓哄ぇ浜哄甫鏉ュ舰璞$殑缇婄敓鑲栨晠浜嬫潵鍘 涓哄瀛愬甫鍘诲揩涔愮殑鐢熻倴鍥剧敾鏁呬簨闃呰
    璋堣皥鎬庢牱瀛﹀ソ鏁板_鑻忔闈-涓鐢熸枃搴
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涓婁紶浜庯細2015-06-17

绮変笣閲忥細25

陕西快三交流群—官方网址22270.COM瓒佺幇鍦ㄧ殑鍙屾墜杩樿兘鎷ユ姳褰兼锛岃秮鎴戜滑杩樿兘鍛煎惛锛屽幓瑙佷綘鎯宠鐨勪汉锛屽仛浣犳兂鍋氱殑浜嬨

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陕西快三交流群—官方网址22270.COM鈥擲yk鍦ㄤ笉鍚屼钩鑵虹梾鍙樼粍缁囦腑鐨勮〃杈惧強涓村簥棰樻剰涔

涓嬭浇绉垎锛1250

鍐呭鎻愮ず锛 澶嶆棪澶у纭曞+瀛︿綅璁烘枃陕西快三交流群—官方网址22270.COM鈥擲yk鍦ㄤ笉鍚屼钩鑵虹梾鍙樼粍缁囦腑鐨勮〃杈惧強涓村簥鎰忎箟濮撳悕锛氳档楣忕敵璇峰浣嶇骇鍒細纭曞+涓撲笟锛氬绉戝锛堟櫘澶栫锛夋寚瀵兼暀甯堬細鐜嬬孩楣20090415 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂嚿挛骺烊涣魅骸俜酵22270.COM鈥擲yk鍦ㄤ笉鍚屼钩鑵虹梾鍙樼粍缁囦腑鐨勮〃杈惧強涓村簥鎰忎箟涓枃鎽樿鐩殑锛氭帰璁ㄧ氦缁村泭鎬т钩鑵虹梾銆佺檶鍓嶆湡鐥呭彉銆佷钩鑵虹檶鍜屼钩鑵虹檶鏃佹甯哥粍缁囦腑鎶戠檶鍩哄洜SYK鐨勮泲鐧借〃杈剧殑宸紓锛屽苟姣旇緝Syk鐨勮〃杈句笌鑲跨槫澶у皬銆佹穻宸寸粨杞Щ銆佺梾鐞嗗垎鏈熴丒R銆丳R銆乸53鍜孒 ER2锛弉eu鐨勫叧绯汇傚璞″拰鏂规硶锛氱敤Supervi onTM 浜屾鍏嶇柅缁勫寲妫娴20渚嬬氦缁村泭鎬т钩鑵虹梾銆16渚婦IN 2( 瀵肩鍘熶綅鐧岋紝涓骇鍒) 銆168渚嬫蹈娑︽у绠$檶鍜95渚嬬檶鏃佹甯哥粍缁囦腑Syk铔嬬櫧鐨勮〃...

鏂囨。鏍煎紡锛歅DF| 娴忚娆℃暟锛23| 涓婁紶鏃ユ湡锛2015-06-17 22:32:20| 鏂囨。鏄熺骇锛
澶嶆棪澶у纭曞+瀛︿綅璁烘枃陕西快三交流群—官方网址22270.COM鈥擲yk鍦ㄤ笉鍚屼钩鑵虹梾鍙樼粍缁囦腑鐨勮〃杈惧強涓村簥鎰忎箟濮撳悕锛氳档楣忕敵璇峰浣嶇骇鍒細纭曞+涓撲笟锛氬绉戝锛堟櫘澶栫锛夋寚瀵兼暀甯堬細鐜嬬孩楣20090415 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂嚿挛骺烊涣魅骸俜酵22270.COM鈥擲yk鍦ㄤ笉鍚屼钩鑵虹梾鍙樼粍缁囦腑鐨勮〃杈惧強涓村簥鎰忎箟涓枃鎽樿鐩殑锛氭帰璁ㄧ氦缁村泭鎬т钩鑵虹梾銆佺檶鍓嶆湡鐥呭彉銆佷钩鑵虹檶鍜屼钩鑵虹檶鏃佹甯哥粍缁囦腑鎶戠檶鍩哄洜SYK鐨勮泲鐧借〃杈剧殑宸紓锛屽苟姣旇緝Syk鐨勮〃杈句笌鑲跨槫澶у皬銆佹穻宸寸粨杞Щ銆佺梾鐞嗗垎鏈熴丒R銆丳R銆乸53鍜孒 ER2锛弉eu鐨勫叧绯汇傚璞″拰鏂规硶锛氱敤Supervi onTM 浜屾鍏嶇柅缁勫寲妫娴20渚嬬氦缁村泭鎬т钩鑵虹梾銆16渚婦IN 2( 瀵肩鍘熶綅鐧岋紝涓骇鍒) 銆168渚嬫蹈娑︽у绠$檶鍜95渚嬬檶鏃佹甯哥粍缁囦腑Syk铔嬬櫧鐨勮〃杈撅紝骞剁敤鍏嶇柅缁勫寲鏂规硶妫娴168渚嬩钩鑵虹檶缁勭粐涓璄R銆丳R銆乸53銆丠 ER2锛弉eu琛ㄨ揪鐨勬儏鍐点傜粨鏋滐細绾ょ淮鍥婃т钩鑵虹梾銆丏IN 2銆佷钩鑵虹檶鍙婄檶鏃佹甯哥粍缁囦腑Syk鐨勮〃杈鹃槼鎬х巼鍒嗗埆涓90锛(18锛20渚)銆5096(8锛16渚)銆34锛52锛(58锛168渚)銆78锛95锛(75锛95渚)銆備钩鑵虹檶涓庣氦缁村泭鎬т钩鑵虹梾(X=22锛84锛屽昂O 锛005)銆佺檶鏃佹甯哥粍缁(鑳47锛91锛屽昂0锛005)涓璖yk琛ㄨ揪鐜囧樊寮傛湁鏄捐憲鎰忎箟銆侱IN 2涓庣氦缁村泭鎬т钩鑵虹梾(鑳7锛7887锛屽昂O 锛010)銆佺檶鏃佹甯哥粍缁(鑳4锛646锛屽昂0锛05)涓璖yk琛ㄨ揪鐜囧樊寮傛湁鏄捐憲鎰忎箟銆陕西快三交流群—官方网址22270.COMSyk鐨勮〃杈句笌鑲跨槫澶у皬銆佹穻宸寸粨杞Щ銆佺梾鐞嗗垎鏈熴丒R銆丳R銆乸53銆丠 ER2锛弉eu鍧囨棤鏄庢樉鐩稿叧鎬с傜粨璁猴細Syk鍦ㄧ氦缁村泭鎬т钩鑵虹梾銆佺檶鏃佹甯哥粍缁囥佺檶鍓嶆湡鐥呭彉鍜屼钩鑵虹檶涓〃杈剧巼渚濇闄嶄綆銆傚叧閿瘝锛氳劸閰皑閰告縺閰(Syk)锛屼钩鑵虹檶锛岀檶鍓嶆湡鐥呭彉锛岀氦缁村泭鎬т钩鑵虹梾锛屽厤鐤粍鍖栦腑鍥惧垎绫诲彿锛歊737锛93 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂嘐xpressi onofSyki n D i fferent Brest Lesi ons andThei r Cl i ni calSi gni fi canceAbstractO bj ecti veTo eval uate the di fferences ofSyk gene expressi oni n hum anbreastfi broadenosi s銆乨uctali ntraepi thel i al neopl asi a2銆乥reastcancer andadj acentnorm alti ssue锛宎nd tostudythe correl ati on ofexpressi onofSyk genew i th tum orsi ze銆乴 ym phfol l i cl e銆乻tages銆丒R銆丳R銆乸53andH ER2锛弉eu锛庛侻 ethodsIm m unohi stochem i stry( Supervi onTMm ethod) W asused to detect theexpressi onofSyk genei n 20 breast fi broadenosi s銆16 duetali ntraepi thel i al neopl asi a2and 1 68breast cancer(95 adj acentnorm al ti ssue)锛孧 eanw hi l e锛孍R銆丳R銆乸53銆丠ER2锛弉euw eredetected i n 168 breast CanCel "ti ssue w i th i m m unohi stocherni calstai ni ng锛嶳esul ts111eposi ti veratesofSyk gene expressi onw ere 90锛( 18锛20) 銆50锛( 8锛16) 銆34锛52锛( 58锛168) 銆78锛95锛( 75锛95) respecti vel yi n breast fi broadenosi s銆乨uctali ntraepi thel i al neopl asi a2銆乥reastcancer ti ssue andadj acentnorm al ti ssue锛嶵heposi ti ve expressi onrate ofSykW assi gni fi cantl yl ow er i n the breast CanCerti ssue than those i n the breast fi bm adenosi s(r=22锛84锛孭<0锛005)andthose i n theadj acentnorm al ti ssue(Xe=47锛91锛孭<0锛005)锛嶵heposi ti ve expressi onrate ofSykw assi gni fi cantl yl ow er i n ductali ntraepi thel i al neopl asi a2than those i n the breastfi broadenosi s(Xe=7锛7887锛孭<0锛010)and those i n theadj acentnorm al ti ssue of breastcancer(Xe=4锛646锛孭<0锛05)锛嶹 e di d not fi ndanycorrel ati onbetw een reducti on ofSyk gene expressi oni nbreast CanCer ti ssue andcl i ni copathol ogi cfactors or otherprognosti cm arkers i n ourseri esstudy锛嶤oncl usi onProgressi vel oss ofSyk geneexpressi on duri ng progressi onfromnorm al toD CI S to i nvasi ve tum or锛嶯 o correl ati on betw een reducti onofSyk gene expressi oni nbreast CanCer ti ssueandcl i ni copathol ogi cfactors or otherprognosti cm arkers锛4 澶嶏紟鏃ワ紟澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂嘖eyw ordsspl een tyrosi neki nase(syk)锛宐reast cancer锛宲recancerousl esi on锛宐reast fi broadenosi s锛宭 m m unohi stoehem i stry5 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂囧墠瑷涔宠吅鐧屾槸濂虫ф渶甯歌鐨勬伓鎬ц偪鐦や箣涓锛屼钩鑵虹檶鐨勫彂鐢熸槸涓涓鍥犵礌鐩镐簰浣滅敤鐨勭粨鏋滐紝鍏朵腑鍖呮嫭鐧屽熀鍥犵殑婵娲诲拰鎶戠檶鍩哄洜鐨勫彉寮傚拰缂哄け銆傜幇鍦ㄥ凡鐭ョ殑鐧屽熀鍥燞 ER2锛弉eu鐨勮繃琛ㄨ揪涓庝钩鑵虹檶鐨勫鍙戝強杩滃杞Щ澧炲姞鐩稿叧锛屽苟鏈夐拡瀵规у湴闈跺悜娌荤枟( 鍗曞厠闅嗘姉浣撴不鐤) 銆傛姂鐧屽熀鍥爌53鐨勭獊鍙樹篃涓庝钩鑵虹檶鐨勯鍚庡樊鐩稿叧銆傝孊RCAI鍜孊RCA2绐佸彉鍙互鏄庢樉鎻愰珮涔宠吅鐧岀殑鍙戠梾鐜囥係YK鍩哄洜鏈鍒濇槸鐢辨棩鏈鑰匱鍢秅um 绛夈111991骞翠粠鐚劸cDN A鍏嬮殕鍑烘潵锛屽叾缂栫爜铔嬬櫧鏄竴绉嶉潪鍙椾綋鍨嬮叒姘ㄩ吀婵閰讹紝鍛藉悕涓鸿劸閰皑閰告縺閰( spl een tyrosi neki nase锛孲yk)銆傛渶鍒濆Syk鐨勭爺绌堕泦涓湪瀹冨閫犺缁嗚優灏ゅ叾鏄厤鐤粏鑳炰綔鐢ㄧ殑鎺㈣锛屽B娣嬪反缁嗚優銆乀娣嬪反缁嗚優銆佽灏忔澘銆佽嚜鐒舵潃浼ょ粏鑳炵瓑銆陕西快三交流群—官方网址22270.COMSada鎺2銆戣涓猴紝Svk鍩哄洜鏄竴绉嶅欓夋姂鐧屽熀鍥狅紝鍏惰〃杈句骇鐗﹕)rl (鐨勭己澶变細浣垮厤鐤粏鑳炲彂鑲层佹垚鐔熼殰纰嶏紝閲嶈呬細瀵艰嚧閲嶇棁鑱斿悎鍏嶇柅缂洪櫡鐥(severecom bi nedi m m unodefi ci ency锛宻cn) ) 锛岀敱浜庢満浣撳厤鐤粏鑳炵殑鎴愮啛闅滅锛屾満浣撶殑鍏嶇柅鐩戞祴浼氫笅闄嶏紝浠庤屽绐佸彉銆佸紓甯稿鐢熺殑缁嗚優澶卞幓鍏嶇柅鍔涳紝瀵艰嚧鑲跨槫鐨勫彂鐢熴侰oopm an绛塼涔犲湪2000骞存姤绂忓缓蹇笁鎶宸 鈥旈椤-浜哠yk鍦ㄤ钩鑵虹檶缁勭粐鍜屾甯镐钩鑵虹粍缁囩殑宸紓锛岃繖寮曡捣浜嗕汉浠Syk鍦ㄥ疄浣撹偪鐦ょ殑鍙戠敓銆佸彂灞曡繃绋嬩腑浣滅敤鐨勫箍娉涘叴瓒c傝繎锛孡骞寸爺绌惰〃鏄嶴yk鏄钩鑵虹檶缁嗚優鐢熼暱鍜岃浆绉讳腑閲嶈鐨勬姂鍒跺洜瀛愩傛湰娆$爺绌剁敤Supervi onTM 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2涓8渚嬭〃杈鹃槼鎬э紝闃虫х巼50锛呫備笌绾ょ淮鍥婃т钩鑵虹梾鐩告瘮鍏禨yk琛ㄨ揪鐜囨湁缁熻瀛﹀樊寮(X锛7锛7887锛孭(O 锛010)銆備笌鐧屾梺姝e父缁勭粐鐩告瘮鍏禨yk琛ㄨ揪鐜囨湁缁熻瀛﹀樊寮(鑳4锛646锛宖(O 锛05)銆係yk鐨勮〃杈惧湪涔宠吅鐧屽墠鏈熺梾鍙樹腑宸茬粡鏈夋墍鍑忓皯锛屼笌涔宠吅鐧屼腑鐨凷yk琛ㄨ揪鐜囩浉姣旀棤缁熻瀛﹀樊寮(鑳1锛521锛0锛嶪O <P(O 锛25)銆傚皻涓嶆敮鎸佷钩鑵虹檶杈冪檶鍓嶆湡鐥呭彉涓璖yk琛ㄨ揪鍑忓皯( 瑙佽〃2) 銆傚洓銆丼yk涓庝复搴婄梾鐞嗗弬鏁颁箣闂寸殑鍏崇郴Syk鐨勮〃杈句笌鑲跨槫澶у皬銆佹穻宸寸粨杞Щ鍙婅偪鐦ゅ垎鏈熷潎鏃犳槑鏄剧浉鍏虫( 瑙佽〃3) 銆備簲銆丼yk涓庡叾浠栫梾鐞嗗鎸囨爣涔嬮棿鐨勫叧绯籗yk鐨勮〃杈句笌鑲跨槫鐨凟R銆丳R銆乸53銆丠 ER2鐨勮〃杈惧潎鏃犳槑鏄剧浉鍏虫( 瑙佽〃3) 銆9 澶嶏紟鍨﹀ぇ瀛︿复搴婂尰瀛︿竷骞村埗纭曞+瀛︿綅璁烘枃琛2涔宠吅鐧屻佺檶鏃佹甯哥粍缁囥丏IN 2鍜岀氦缁村泭鎬т钩鑵虹梾涓璖yk鐨勮〃杈炬儏鍐佃〃3涔宠吅鐧屼腑Syk鐨勮〃杈句笌鍚勪复搴婄梾鐞嗗鎸囨爣涔嬮棿鐨勫叧绯10 涓漧 J 锛庝汉瀛︿复搴奍蹇呭tJ l -$IJ 椤簘锛氬浣嶈鏂囧浘l 绾ょ淮鍥婃т钩鑵虹梾銆両) I N 2銆佷钩鑵虹檶鍙妢{锛涳細锛涙梺II锛氬父fl t缁, , t, Syk鍐滆揪I锛11鎬э紡15}J 鎬т緥鏁癏H—|]l J I锛’涓_鈻犫棌 s銆’ k濮恖 r鍙¨ k鈰腑鍥2绾ょ淮鍥4' k-锛呰吅鐥呫佺檶鏃丣 F甯镐钩鑵虹粍缁囥丏IN 2鍜屼钩鑵虹檶Syk琛ㄨ揪鐜囩殑宸墖銏р枲妲 銆佹尯}{锛庝汉瀛︿复锛屾湯鍖诲{浜岋紝1i 鍒跺抚鍗佸浣嶈鏂囧浘3绾ょ淮鍥婃т钩鑵虹梾锛孲yk鍛堥槼鎬ц〃杈( 鍏嶇柅缁嗗寲Supervi onTM 娉曪紝× 200)鍥4绾ょ淮鍥婃т钩鑵虹梾锛孲yk鍛堥槼鎬ц〃杈 ( 鍏嶇柅缁勫寲Supervi onTM 娉曪紝× 400) 濂矵 浜哄涓淬庢湳闃C锛歭 $aJ 棰{锛氬浣嶈鏂囧浘5绾ょ淮鍥婃т钩鑵虹梾锛孲yk鍛堥槾鎬ц〃杈( 鍏嶇柅缁勫寲Supervi onTM 娉曘× 200)鍥6绾ょ淮鍥婃т钩鑵虹梾锛孲yk鏄熼槾鎬ц〃杈( 鍏嶇柅缁勫寲Supervi onTM 娉曪紝× 400) 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鍜岃泲鐧( 铔嬬櫧璐ㄦ枒杩规硶W estern bl ot) 鍒欒〃杈惧噺灏戞垨缂哄け銆傛甯镐钩鑵虹粍缁囧拰涔宠吅鐧岀粍缁囩殑鍘熶綅鏉備氦瀹為獙楠岃瘉浜哠yk鍦ㄦ甯镐钩鑵轰笂鐨拰姝e父涔宠吅涓婄毊缁嗚優鏍狹 CFIO A涓〃杈撅紝鍦ㄥ師浣嶇檶涓〃杈惧彈鎶戝埗锛岃屽湪渚佃涔宠吅鐧屼腑琛ㄨ揪缂哄け銆傛帴鐫浠栦滑鍒╃敤瑁搁紶鍋氬姩鐗╁疄楠屾樉绀猴紝鍦⊿yk琛ㄨ揪缂哄け鐨勪钩鑵虹檶缁嗚優涓紝杞煋閲庣敓鍨婼YK鍩哄洜锛屽彲浠ユ槑鏄炬姂鍒惰偪鐦ょ殑鐢熼暱鍜岃繙澶勮浆绉汇傜浉搴旂殑锛屼钩鑵虹檶缁嗚優杩囧害琛ㄨ揪鏃犳縺閰舵椿鎬х殑Syk鍒欐樉钁楁彁楂樹簡鑲跨槫鐨勫彂鐢熷拰鐢熼暱銆傛湰娆¤瘯楠屼腑涔宠吅鐧屼腑Syk( 铔嬬櫧) 琛ㄨ揪闃虫х巼[ 34锛52锛( 58锛168渚) ] 鏄庢樉浣庝簬鐧屾梺姝e父缁勭粐[ 78锛95锛( 75锛95渚) ]18 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁锛歜瀛︿綅璁烘枃(鑸47锛91锛屽昂0锛005)锛屾槑鏄句綆浜庣氦缁村泭鎬т钩鑵虹梾[90锛(18锛20渚)](, Ie=22锛84锛孭( O 锛005) 銆傝繖涓庝钩鑵虹檶涓璖yk琛ㄨ揪缂哄け鏄畬鍏ㄧ浉绗︾殑锛岀鍚堟姂鐧屽熀鍥犲湪鑲跨槫涓〃杈惧噺灏戞垨缂哄け銆傜氦缁村泭鎬т钩鑵虹梾鏄钩鑵虹氦缁寸粍缁囧強涓婄毊澧炵敓浼村泭鑲垮舰鎴愪笌澶嶆棫涓嶅叏鐨勪竴绉嶄钩鑵虹粨鏋勭磰涔辩殑鐤剧梾銆傚叾鐥呯悊褰㈡佸鏍凤紝鍛藉悕涓嶄竴锛岃タ鏂瑰鑰呭绉扮氦缁村泭鎬т钩鑵虹梾锛涘湪鎴戝浗锛屽泭鎬ф敼鍙樺皯瑙侊紝澶氫互鑵轰綋澧炵敓涓轰富锛屾晠绉颁钩鑵哄鐢熺棁銆備笘鐣屽崼鐢熺粍缁囩粺绉拌壇鎬т钩鑵虹粨鏋勪笉鑹傛湰鐥呭紑濮嬬敱鑵轰笂鐨鐢燂紝閫愭笎鍑虹幇绾ょ淮缁勭粐澧炵敓銆佺氦缁村泭鎬у鐢熷拰绾ょ淮鑵虹槫褰㈡垚绛夌粍缁囧舰鎬佺殑鐥呯悊鏀瑰彉銆傜柧鐥呭彲浠ラ愭杩涘睍锛屼篃鍙互鍋滄浜庢煇涓樁娈佃岃嚜鎰堛傜氦缁村泭鎬т钩鑵虹梾鏄竴绉嶈壇鎬х梾鍙橈紝鍩烘湰涓嶄細鐧屽彉锛屼篃涓嶅簲瑙嗕负鐧屽墠鐥呭彉銆6銆戙7銆戙傚绠″唴澧炵敓鎬х梾鍙樻垨绉板绠′笂鐨唴鑲跨槫锛忕槫鍙(ductal i n浠僡鍗癷 m di al noapl asi a,DIN )锛屽彂鐢熶簬鏈ⅱ瀵肩-d, 鍙跺崟浣(term i nal duct锛10bul anm i t锛孴DLU)銆傛渶鏂扮殑W H O鐨勫浗闄呰偪鐦ゅ鍒嗙被娉(i ntcm ati onal璁や负DIN 鏄竴绉嶇檶鍓嶆湡鐥呭彉锛屽叾娌荤枟涓庨鍚庝笌涔宠吅鐧岃骏寮傘侱IN IA涓哄钩鍧﹀瀷涓峜l assi fi cati on of di sease for ontol ogy, ICD锛嶰 )銆愶紟7銆戝吀鍨嬫(fl at epi thel i al atypi a)锛屾槸涓鏂板垎绫荤被鍨嬶紝鐢3锝5灞傝交搴︿笉鍏稿瀷缁嗚優缁勬垚锛屽彲鏈夊井灏忛挋鍖栥侱 IN IB鍗冲師鍏堢殑瀵肩涓婄毊涓嶅吀鍨嬪鐢( atypi calductalhyperpl asi a锛孉DH )锛孌IN IC锛氫綆绾у埆瀵肩鍘熶綅鐧(ducalcarci nom a i nsi tu锛孌CIS)锛屾棤鍧忔绮夊埡鍑虹幇锛屾晠鐜板湪璇婃柇涓嶅啓“ 鐧"銆侱IN 2锛氫腑绾у埆DCIS锛屾湁鍧忔銆侀挋鍖栥侱IN 3锛氶珮缁傚埆DCIS锛屽ぇ閲忓潖姝荤灞戠矇鍒猴紝涓庝互寰鐨凞CIS绮夊埡鍨嬬浉褰擄紝鍏锋湁鑲跨槫澶с佹牳鍒嗙骇楂樸佸涓績鎬с佸井娴告鼎銆佹槗澶嶅彂銆佺紦瑙f湡鐭佷镜琚у拰鐧屽熀鍥犻珮琛ㄨ揪绛夌壒寰併侱CIS鐥呬汉涓綅骞撮緞45""65宀侊紝鏈夊勾杞诲寲鐨勮秼鍔裤備互寰澶氱敱浣撴鍙戠幇锛屼粎<1锛咃紝鐩墠杈10锛"-15锛( 鍗犳墍鏈変钩鑵虹檶鍜岀檶鍓嶆湡鐥呭彉鐨勬瘮渚) 銆傜浉瀵瑰嵄闄╁害(rel ati veri sk锛孯R)涓8"10銆傝嚜鐒剁梾绋嬪皻闅剧‘瀹氾紝1锛3鍙戝睍涓烘蹈娑︾檶銆8銆戙傛湰娆″疄楠岄夊彇DIN 2鐨勬爣鏈綔涓虹檶鍓嶆湡鐥呭彉缁勶紝涓昏鏄洜涓篋IN 2鐨勮涓轰粙浜庝綆绾у埆DCIS鍜岀矇鍒哄瀷DCIS涔嬮棿锛屽湪鎴戦櫌鐧屽墠鏈熸偅鑰呬腑鏁扮洰鎵鍗犳瘮渚嬫渶澶с傞夊彇鍗曚竴鐥呯悊瀛︾被鍨嬫爣鏈洿鍙互鎺掗櫎鍏朵粬鍥犵礌瀵瑰疄楠岀殑褰卞搷銆侻 oroni 绛夈9銆戦氳繃鍘熶綅鏉備氦鎶鏈樉绀猴紝鍦ㄦ甯镐钩鑵虹粍缁囷紟涓嶅吀鍨嬪鐢燂紟鍘熶綅鐧岋紟娴告鼎鎬х檶涓紝Sykm RN A鏄愭鍑忓皯鐨勩備粬浠繕姣旇緝浜嗘甯镐钩鑵虹粍缁囧拰涔宠吅鐧屾梺姝e父缁勭粐涓璖yk m RN A锛屽彂鐜颁钩鑵虹檶鏃佹甯哥粍缁囩殑Sykm RN A宸叉湁鍑忓皯銆備粬浠氳繃姣旇緝Ki 67鍙戠幇Syk m RN A鐨勮〃杈惧拰鑲跨槫缁嗚優澧炴畺鏄憟璐熺浉鍏崇殑銆俁epana绛夈恗 銆戦氳繃鍏嶇柅缁勫寲鏂规硶涔熷緱鍒扮浉鍚岀殑缁撹锛歋yk鐨勮〃杈句笌涔宠吅鐧岀殑澧炲煎拰渚佃鏄19 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁锛欽 锛氬浣嶈鏂囧憟鍙嶆瘮鐨勩傛湰瀹為獙閫氳繃姣旇緝涔宠吅鐧屻佺檶鏃佹甯哥粍缁囥丏IN 2銆佺氦缁村泭鎬т钩鑵虹梾缁勭粐Syk琛ㄨ揪鐨勫樊寮傦紝鍙戠幇Syk鍦ㄧ氦缁村泭鎬т钩鑵虹梾鑷崇檶鏃佹甯哥粍缁囪嚦DIN 2鑷充钩鑵虹檶涓〃杈鹃槼鎬х巼渚濇闄嶄綆銆傛缁撴灉涓嶮 oroni 绛夌殑缁撴灉鐩哥锛屼絾绾ょ淮鍥婃т钩鑵虹梾涓庣檶鏃佹甯镐钩鑵虹粍缁囪〃杈剧巼宸紓鏃犵粺璁″鎰忎箟锛屽彲鑳戒笌绾ょ淮鍥婃т钩鑵虹梾鐥呬緥鏁拌緝灏(淇20)鏈夊叧锛涗钩鑵虹檶杈僁IN 2涓殑Syk琛ㄨ揪闃虫х巼闄嶄綆锛屼絾娆″樊鍒篃鏃犵粺璁″鎰忎箟锛屽彲鑳戒笌DIN 2渚嬫暟杈冨皯( 鑵=16) 鏈夊叧銆傝繘涓姝ュ疄楠屽彲浠ユ墿澶х氦缁村泭鎬т钩鑵虹梾鍜孌IN 2鐨勫彇鏉愭暟浠ヨ揪鍒伴鏈熸晥鏋溿俻53鍩哄洜瀹氫綅浜17PI锛屾槸鐜板湪鐮旂┒杈冨鍏鐨勬姂鐧屽熀鍥狅紝p53浣滀负涓绉嶆牳杞綍璋冩帶鍥犲瓙( TA) 锛岃兘涓婅皟鍜屼笅璋冭浆褰曟按骞筹紝閲庣敓鍨媝53鑳借瀵肩粏鑳炲噵浜′笌DN A淇銆11銆戙侽 kam ura鎺12銆戣涓篠yk鍩哄洜鐨勮〃杈炬槸p53渚濊禆鎬х殑锛屽湪鑲跨槫鐢熸垚杩囩▼涓璸53鐨勫姛鑳戒抚澶变細瀵艰嚧Syk鐨勬椿鎬т笅闄嶃傛湰娆¤瘯楠屼腑p53閲庣敓鍨嬬殑Syk闃虫х巼涓27锛87锛(17锛61)锛岀獊鍙樺瀷涓璖yk闃虫х巼涓38锛32锛(41锛107)銆備絾宸埆骞舵棤缁熻瀛︽剰涔( r--I锛876锛孎>0锛05) 銆傛湰娆$爺绌跺苟涓嶈兘璇存槑Syk鐨勮〃杈句笌p53鏈夋槑鏄惧叧绯汇傚鏋滄墿澶ф牱鏈噺锛屽彲鑳藉彲浠ュ緱鍑轰笌O kam ura鐩稿悓鐨勭粨璁恒侶 er-2锛弉eu鏄〃鐨敓闀垮洜瀛愬彈浣撳鏃忔垚鍛樹箣涓锛屽畾浣嶄簬鏌撹壊浣17q21锛屾槸鍏鐨勭檶鍩哄洜銆侶 er-2铔嬬櫧鍦ㄦ甯哥殑涔宠吅缁嗚優( 鐢氳嚦涓嶅吀鍨嬪鐢) 涓綆琛ㄨ揪锛岃屽湪20锛-30锛呯殑涔宠吅鐧屼腑鍙繃搴﹁〃杈俱恖 "銆侶 er-2锛弉eu鍩哄洜鐨勬墿澧炲彲鐢ㄨ崸鍏夊師浣嶅垎瀛愭潅浜( FISH ) 妫娴嬫垨Southern Bl ot妫娴嬶紝鏈鐮旂┒浣跨敤鐨勫厤鐤粍鍖栨柟娉曟娴婬 er-2锛弉eu锛屽苟涓嶈兘瀹屽叏鍙嶆槧H er-2锛弉eu鐨勯槼鎬х巼锛屽彧鑳界矖鐣ユ瘮杈僑yk涓嶩 er-2锛弉eu鐨勫叧绯汇侰arter绛夈14銆戣涓猴紝SYK涓嶩ER-2锛弉eu鏄竴瀵瑰姛鑳界浉鍙嶇殑鎶戠檶锛忕檶鍩哄洜锛孒 ER-2锛弉eu鐨勮繃搴﹁〃杈惧彲璇卞琛绠″唴鐨粏鑳炵殑鏀剁缉锛屼粠鑰屼娇鑲跨槫缁嗚優鏄撲簬绌胯繃琛绠″睆闅滐紝鏄撲簬鍙戠敓杞Щ锛岃孲yk鍙綔涓鸿偪鐦ょ殑鎶戝埗鍓傦紝鍙互鎶慡U H ER-2锛弉eu鏀剁缉琛绠″唴鐨粏鑳炵殑浣滅敤銆備絾鏈鐮旂┒骞舵湭鍙戠幇Syk涓嶩 er-2锛弉eu鏈夋槑鏄剧浉鍏虫(鏂4锛204锛岃嚜鐢卞害3锛孭>O 锛05)銆侫btahi an绛塼宸с戠爺绌舵寚鍑哄湪鑳氳儙鏃舵湡Syk锛弒l p276淇″彿閫斿緞瀵规穻宸寸鍙戣偛鍙婃穻宸寸鍜岃绠$郴缁熺殑鍒嗙鏈夐噸瑕佷綔鐢紝Syk锛弒l p276鐨勭己闄峰鑷磋绠℃墿寮犮佹壄鏇层佹暟閲忓澶氬強娣嬪反绠¤〃闈㈡爣蹇楄〃杈惧鍔狅紝骞跺舰鎴愭穻宸村拰琛娑茬殑寮傚父鍒嗘祦銆侸 i 绛夈16銆戠爺绌跺彂鐜帮紝娣嬪反鍐呯毊缁嗚優鍦ㄧ粏鑳炲鍩鸿川涓殑鐢熼暱銆佽縼绉诲拰褰㈡垚绠$寤哄揩涓夋妧宸 鈥旈椤-鍧囦緷闈燬yk锛廠LP76銆乂EGF2C锛廌锛廣EGFR23鍜孭rox21鐨勭浉浜掍綔鐢ㄣ係ebzda绛夈17銆戞姤绂忓缓蹇笁鎶宸 鈥旈椤-锛屽惊鐜唴鐨墠浣撶粏鑳( CEPs) 琛ㄨ揪Syk锛屽湪鎼哄甫娣嬪反鏍囪( LYVE銆乂EGFR3) 鐨凜EPs浜х敓杩囩▼涓渶瑕丼yk鐨勫弬涓庛備竵姘告枌绛夈怚 8銆戠爺绌跺彂鐜版湁娣嬪反缁撹浆绉荤殑涔宠吅鐧岀粍缁囦腑Syk鐨勮〃杈鹃槼鎬х巼瑕佹槑鏄 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂囦綆浜庢棤娣嬪反缁撹浆绉荤殑涔宠吅鐧( n-=40) 銆俉 AN G绛夈191閫氳繃妫娴6l 渚嬭儍鐧岀粍缁囦腑Syk锛屽緱鍒扮浉浼肩殑缁撹锛氭湁娣嬪反缁撹浆绉荤殑鑳冪檶缁勭粐Syk琛ㄨ揪闃虫х巼瑕佹槑鏄句綆浜庢棤娣嬪反缁撹浆绉荤粍銆傝繖浜涚爺绌跺潎鎻恎Syk鐨勮〃杈剧己澶变笌鑲跨槫鐨勬穻宸寸粨杞Щ鍙兘鐩稿叧銆傛湰娆¤瘯楠屼腑鏈夋穻宸寸粨杞Щ鐨勪钩鑵虹檶涓璖yk鐨勮〃杈剧巼30锛99锛(22锛71)锛屾棤娣嬪反缁撹浆绉荤粍37锛11锛( 36锛97) 銆備絾姝ゅ樊鍒苟鏃犳槑鏄剧粺璁″宸紓( r=0锛6809锛屼箖O 锛05) 銆俆oyam a绛夈20銆戦氳繃姣旇緝90渚嬩钩鑵虹檶缁勭粐Syk m RN A琛ㄨ揪鍑忓皯鍜岀己澶变笌鑲跨槫鐨勫ぇ灏忋佽厠绐濇穻宸寸粨杞Щ銆佽偪鐦ょ殑绫诲瀷( 灏忓彾鏉ユ簮杩樻槸瀵肩鏉ユ簮) 銆丒R銆丳R銆乸53銆丠ER2鐨勫叧绯伙紝鍙戠幇鍧囨棤鏄庢樉缁熻瀛︽剰涔夛紝Gol ouh绛夈211閫氳繃鐮旂┒ER闃虫х殑涔宠吅鐧屼篃鍙戠幇Syk鐨勮〃杈句笌鑲跨槫澶у皬銆佽偪鐦ょ被鍨嬨佹穻宸寸粨杞Щ銆佸垎鏈熷強PR鐨勭姸鎬佸潎鏃犲叧銆傛渶杩戞湰瀹為獙涔熻幏寰椾簡绫讳技鐨勭粨璁恒俆oyaraa绛夈20銆戣繕閫氳繃姣旇緝涔宠吅鐧屽拰鐧屾梺姝e父缁勭粐涓璖yk m RN A鐨勮〃杈惧樊寮傦紝鍙戠幇Syk m RN A琛ㄨ揪鍑忓皯鍜岀己澶辩殑鎮h咃紝鍏舵棤鐦ょ敓瀛樼巼鍑忓皯锛岃繙澶勮浆绉荤巼澧炲姞锛屾彁绀篠yk鏈夊彲鑳芥槸涔宠吅鐧岀嫭绔嬬殑棰勫悗鎸囨爣銆侱ej m ek绛夈22銆戠殑鐮旂┒涔熸寚鍑篠yk鑱斿悎W nt锛5a(涓涓狦铔嬬櫧鍋惰仈鍙椾綋)鍦ㄦ寚瀵间钩鑵虹檶鐨勯鍚庢柟闈㈡湁鐙壒鑰岄噸瑕佺殑浣滅敤銆傛湰瀹為獙涓钩鑵虹檶鐥呬緥涓璖yk鍛堜綆琛ㄨ揪鐨勬偅鑰呮槸鍚﹀瓨鍦ㄦ棤鐦ょ敓瀛樼巼鍑忓皯鍜岃繙澶勮浆绉荤巼澧炲姞鏈夊緟浜庤繘涓姝ラ殢璁裤傚湪鑷劧鍙戠敓鐨勪钩鑵鸿偪鐦や腑锛岀洰鍓嶅皻鏈彂鐜癝YK鍩哄洜绐佸彉浣撴垨鍚屾簮鏌撹壊浣撶己澶憋紝瀵艰嚧SYK鍩哄洜娌夐粯鐨勭‘鍒囨満鍒朵粛涓嶆竻妤氥俌uan绛夈23銆戝彂鐜癝YK鍩哄洜鍚姩瀛怌pG宀涜皟鑺傚簭鍒楃殑楂樼敳鍩哄寲锛岃岃繖绉嶉珮鐢插熀鍖栦笌Syk m RN A鐨勮〃杈剧己澶辨槸寮虹儓鐩稿叧鐨勩傝繖鎻愮ずSYK鍩哄洜鍚姩瀛怌pG宀涜皟鑺傚簭鍒楃殑楂樼敳鍩哄寲鏄鑷碨yk鍩哄洜娌夐粯鐨勫師鍥犱箣涓銆備粬浠繘涓姝ュ湪Syk琛ㄨ揪缂哄け鐨勭粏鑳炰腑浣跨敤鍘荤敳鍩哄寲璇曞墏5涓姘-2-鑴辨哀鑳炶嫹( AZA) 锛屽彲浠ヤ娇Syk鍐嶈〃杈撅紝杩涜屽彲浠ユ姂鍒朵钩鑵虹檶缁嗚優鐨勪镜琚姏銆24銆戙傝繖涓轰钩鑵虹檶鐨勬不鐤楁彁渚涗簡涓绉嶆柊鐨勬濊矾銆傛渶杩戠殑鐮旂┒琛↖j fJ Syk鍦ㄥ疄浣撹偪鐦や腑锛屽涔宠吅鐧屻佽儍鐧屻2鍒拰鑲濈粏鑳炶倽鐧屻261涓叿鏈夊垽鏂鍚庣殑浣滅敤銆傜浉淇¢殢鐫鐮旂┒鐨勪笉鏂繘灞曪紝Syk灏嗘湁鏈涘儚H ER2涓鏍凤紝鎴愪负涔宠吅鐧屾柊鐨勯鍚庢寚鏍囧強鍒嗗瓙闈剁偣銆2l 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁浜1锛氬浣嶈鏂囧弬鑰冩枃鐚甌ani guchi t Kobayashi t KondoJ锛宑t a1锛嶮 ol ecul arcl oni ngof aporci negene sykthat encodes a72· kDaprote锛歩 n-tyrosi neki naseshow i ng hi gh suscepti bi l i tytoproteol ysi s[J]锛嶫Bi olChcm , 1991銆266( 24) 锛15790· 15796锛嶴adaKTakanoL Yenagi S锛宔t a1锛嶴tructure and Functi on ofSyk Protei n-tyrosi ne ki nase[j J銆戯紟JBi ochem(Tokyo)锛2001锛1 30(2)锛177-186锛嶤oopm an PJ 锛孌o M T, Banh M 锛宔ta1锛嶵heSyk tyrosi neki nasesuppresses m al i gnant grow th of hum an breastcancercei l s銆怞 銆戯紟N ature, 2000锛406(6797)锛742-747锛嶵um erM 锛孲chw ei ghoffer E銆侰ol ucci F' ct a1锛嶵yrosi neki naseSYK锛歟ssenti al functi ons for i m m unoreneptorsi gnal i ng[J ]锛嶫Im m 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nases锛孭TKs)鏄竴绫诲偓鍖朅TP涓婁斧锛庣7閰歌浆绉诲埌铔嬬櫧閰皑閰告畫鍩轰笂鐨勬縺閰讹紝鑳藉偓鍖栧绉嶅簳鐗╄泲鐧借川閰皑閰告畫鍩虹7閰稿寲銆侾TKs涓庣粏鑳炵殑澧炴畺銆佸垎鍖栥佽縼绉诲拰鍑嬩骸鏈夊叧銆傝縿浠婂彂鐜扮殑铔嬬櫧閰皑閰告縺閰朵腑澶氭暟鏄睘浜庤嚧鐧孯N A鐥呮瘨鐨勭檶鍩哄洜浜х墿銆恖 銆戙傛牴鎹甈TK鏄惁瀛樺湪浜庣粏鑳炶啘鍙椾綋鍙皢鍏跺垎鎴愰潪鍙椾綋鍨嬪拰鑶滃彈浣撳瀷銆係YK鍩哄洜鏈鍒濇槸鐢辨棩鏈鑰匱afl i gucl l i 绛夈2銆1991骞翠粠鐚劸cDN A鍏嬮殕鍑烘潵锛屽叾缂栫爜铔嬬櫧鏄竴绉嶉潪鍙椾綋鍨嬮叒姘ㄩ吀婵閰讹紝鍛藉悕涓鸿劸閰皑閰告縺閰(spl een tyrosi ne l 銆恑 n楣锛孲yk)銆傛渶鍒濆Syk鐨勭爺绌堕泦涓湪瀹冨閫犺缁嗚優灏ゅ叾鏄厤鐤粏鑳炰綔鐢ㄧ殑鎺㈣锛屽B娣嬪反缁嗚優銆乀娣嬪反缁嗚優銆佽灏忔澘銆佽嚜鐒舵潃浼ょ粏鑳炵瓑銆係ada绛夈3銆戣涓猴紝SYK鍩哄洜鏄竴绉嶅欓夋姂鐧屽熀鍥狅紝鍏惰〃杈句骇鐗㏒yk鐨勭己澶变細浣垮厤鐤粏鑳炲彂鑲层佹垚鐔熼殰纰嶏紝閲嶈呬細瀵艰嚧閲嶇棁鑱斿悎鍏嶇柅缂洪櫡鐥(severecom bi nedi m m unodefi ci ency, scm ) 锛岀敱浜庢満浣撳厤鐤粏鑳炵殑鎴愮啛闅滅锛屾満浣撶殑鍏嶇柅鐩戞祴浼氫笅闄嶏紝浠庤屽绐佸彉銆佸紓甯稿鐢熺殑缁嗚優澶卞幓鍏嶇柅鍔涳紝瀵艰嚧鑲跨槫鐨勫彂鐢熴侰oopm an绛塼4銆戝湪2000骞存姤绂忓缓蹇笁鎶宸 鈥旈椤-浜哠yk鍦ㄤ钩鑵虹檶缁勭粐鍜屾甯镐钩鑵虹粍缁囩殑宸紓锛岃繖寮曡捣浜嗕汉浠Syk鍦ㄥ疄浣撹偪鐦ょ殑鍙戠敓銆佸彂灞曡繃绋嬩腑浣滅敤鐨勫箍娉涘叴瓒c傛湰鏂囩珷灏盨yk涓庝钩鑵虹檶鐨勫叧绯荤殑鐮旂┒杩涘睍缁艰堪濡備笅銆係YK鍩哄洜鍙婅泲鐧界殑鐞嗗寲鐗圭偣浜篠YK鍩哄洜瀹氫綅浜9鍙锋煋鑹蹭綋q22鍖猴紝SYKm RN A鍏ㄩ暱2672bp锛屽惈1涓唴鍚瓙鍜2涓鏄惧瓙銆傚叾琛ㄨ揪铔婨j Syk鏄竴绉嶉潪鍙椾綋鍨嬮叒姘ㄩ吀婵閰讹紝鍖呭惈629涓皑鍩洪吀娈嬪熀锛屽垎瀛愰噺涓72 kD銆係yk铔嬬櫧鏄疊缁嗚優婵娲讳俊鍙疯浆瀵艰繃绋嬩腑鏈閲嶈鐨勬縺閰讹紝骞惰浣滀负B缁嗚優鍙椾綋( BCR) 淇″彿杞鍒嗗瓙寰楀埌骞挎硾鐨勭爺绌躲係yk涓嶵缁嗚優婵娲讳腑鐨刏AP锛70灞炰簬鍚屼竴铔嬬櫧閰皑閰告縺閰跺鏃忥紝鍏剁壒鐐规槸鍖呭惈鏈変袱涓覆鑱旂殑SH 2缁撴瀯鍩( Srchom ol ogy2dom ai ns) ——SH 2( N ) 鍜孲H 2( C) 浠ュ強涓涓綋鐜伴叒姘ㄩ吀婵閰跺浐鏈夌壒鎬х殑婵閰剁粨鏋勫煙( ki nase) SH l 銆係H 2鏄厤鐤叒姘ㄩ吀鍙椾綋婵娲诲熀搴( i m m unoreceptor tyrosi ne-basedacti vati onm oti fs锛宼rAM ) 鎷涘嫙鐨勯閫夊璞°傝鎷涘嫙N Syk绔嬪嵆鎴愪负Src浣滅敤鐨勭浜屼釜闈剁洰鏍囥傝繘鑰屽彲浠ュ惎鍔˙缁嗚優娲诲寲淇″彿杞鐨勪笁鏉′富瑕侀斿緞寰( 纾疯剛閰拌倢閱囬斿緞銆丮 AP婵閰剁浉鍏抽斿緞鍜岀7閰歌倢閱3婵閰堕斿緞) 锛屾渶缁堟縺娲诲悇绉嶈浆褰曞洜瀛愶紝浣夸箣杩涘叆缁嗚優鏍稿唴锛岃繘鑰屼娇鐩稿簲鐨勫熀鍥犲彂鐢熻浆褰曟縺娲诲嚭鐜颁骇鐗╃殑琛ㄨ揪銆愬紩銆 澶嶄笖澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂嘢yk铔嬬櫧鏈変袱绉嶈〃杈惧舰寮忥紝Syk(L)鏄疭yk鐨勫叏闀垮舰寮忥紝Syk(L)鏈635涓皑鍩洪吀銆係YK鍩哄洜鐢变簬鍦ㄨ浆褰曡繃绋嬩腑閫夋嫨鎬у湴鎷兼帴鍙舰鎴2绉嶈浆褰曞瓙锛岀煭杞綍瀛愬湪鍔熻兘鍩熼棿鍩烞(i nterdom ai n B锛孖DB) 涓婄己澶69涓⒈鍩猴紝鎵缈昏瘧鐨凷yk铔嬬櫧杈冨叏闀跨殑铔嬬櫧[Syk(L)銆戝皯23涓皑鍩洪吀锛岃绉颁负Syk(S)锛孲yk(S)缂哄け鐨勬皑鍩洪吀閮ㄥ垎琚О涓篋EL鍔熻兘鍩熴侺eiW ang绛塠 6] 閫氳繃鐮旂┒鍙戠幇鍦ㄤ钩鑵虹檶涓璖yk( L) 鍜孲yk( S) 鍧囨湁琛ㄨ揪锛岃屽湪姝e父缁勭粐q锛孲yk( S) 娌℃湁琛ㄨ揪锛岄氳繃杞煋Syk( L) 鍙互鎶戝埗鑲跨槫鐨勪镜琚э紝鑰岃浆鏌揝yk( S) 鍒欐病鏈夌被浼兼晥鏋滐紝鎻愮ずSyk( L) 鍏锋湁鎶戝埗鑲跨槫缁嗚優渚佃鎬х殑鍔熻兘銆傝繘涓姝ョ爺绌跺彂鐜颁钩鑵虹檶q涓丼yk( L) 鍙粠缁嗚優鑳炴祮绉讳綅鍒扮粏鑳炴牳鍐咃紝鏍哥Щ浣嶇幇璞′笌Syk( L) 鐨勬姂鐧屽姛鑳藉瘑鍒囩浉鍏炽係yk鎶楄偪鐦ょ殑鏈哄埗Coopm an绛(4J 閫氳繃鍦ㄨ8榧犱綋鍐呰浆鏌撳惈鏈塖yk鍩哄洜鐨凪 DA锛嶮 B-435涔宠吅鐧岀粏鑳烇紝鍙戠幇琛ㄨ揪Syk鐨勪钩鑵虹檶缁嗚優甯稿澶э紝鍚鍙舵牳鐢氳嚦澶氫釜鏍革紝鍑虹幇寮傚父鐨勬湁涓濆垎瑁傦紝琛ㄧ幇涓烘湁涓濆垎瑁備腑鏈熷嚭鐜板涓汉閿や綋鏋併傜敋鑷冲嚭鐜皒鏌撹壊浣撳拰17鍙风潃涓濈偣鐨勬暟閲忛珮浜庢甯搞傜劧鍚庨氳繃鑽у厜鍘熶綅鏉備氦(fl uorescent i nsi tuhybri di zati on锛孎ISH)鍒嗘瀽鍙戠幇寮傚父澧炲ぇ鐨勭粏鑳炴槸瓒呬簩鍊嶄綋銆傝繖浜涚粏鑳炲湪寮傚父鏈変笣鍒嗚鍚庝細鍑虹幇鐢熼暱鍙楅樆锛屼粠鑰屽嚭鐜拌優璐ㄥ垎瑁傚け璐ャ俍yss绛塼7銆戠爺绌跺彂鐜板嚭鐜颁簬涓績浣撶殑Syk鍏锋湁鍌寲娲绘э紝鍦ㄦ湁涓濆垎瑁傞棿鏈熸寔缁〃杈撅紝鍦ㄦ湁涓濆垎瑁傛湡鍒欏洜鍏堕檷瑙c傚悓鏃朵粬涔熷彂鐜颁簡杞煋Syk鍙互浣跨粏鑳炲嚭鐜拌優鏍稿ぇ灏忎笉绛夈佸鏋佹湁涓濆垎瑁傜汉閿や綋鍜屼腑蹇冧綋鏁扮洰澧炲姞銆傜敱浜嶴yk纾烽吀鍖朼-寰铔嬬櫧缇у熀鏈鍖哄煙鍖呭惈鏈夊悓璋冭妭寰瑁呴厤浠ュ強鍔熻兘鐨勫井绠$浉鍏宠泲鐧界浉浜掍綔鐢ㄧ殑浣嶇偣锛屼粠鑰屽彲浠ヨ皟鑺傚井绠★紡寰铔嬬櫧鍗曚綋鐨勫钩琛°傛渶缁堝彲浠ュ奖鍝嶆湁涓濆垎瑁傦紝鍙互璁や负Syk鍙兘鏄氳繃璋冭妭寰绯荤粺鏉ユ姂鍒惰偪鐦ょ粏鑳炵殑鐢熼暱銆侼 F锛嶬B铔嬬櫧鏄敱p65锛弍SO 涓や釜浜氬崟浣嶆瀯鎴愮殑澶氭晥鎬ц浆褰曞洜瀛愶紝鍦ㄦ伓鎬ц偪鐦や腑锛孨 F锛嶬 B鍙備笌鍑嬩骸鐨勮皟鑺傘佽偪鐦ょ殑杩涘睍鍜岃偪鐦ょ粏鑳炲鍖栫枟銆佹斁鐤楃殑鍙嶅簲銆傛澶栵紝N F锛嶬B杩樻槸涓绉嶈偪鐦よ浆绉诲熀鍥狅紝鏈杩戠殑鐮旂┒閮借〃鏄庡叾鍦ㄨ偪鐦よ浆绉讳腑鏈夐噸瑕佷綔鐢ㄣ侼 F锛嶬B婵娲昏繕鍙互淇冭繘U 锛嶱A鐨勫垎娉屻倁-PA鏄竴绉嶄笣姘ㄩ吀铔嬬櫧婵閰讹紝鍦ㄤ汉浣撲腑涓昏浣滅敤涓哄皢绾ゆ憾閰跺師杞彉涓虹氦缁磋泲鐧芥憾瑙i叾锛岃岀氦缁磋泲鐧芥憾瑙i叾鍙互婵娲烩叄鍨嬭兌鍘熼叾锛屼粠鑰岄檷瑙h兌鍘熷強鍩哄簳鑶溿傚湪鑲跨槫鍙戠敓杩囩▼涓紝闄嶈В鍩鸿川铔嬬櫧淇冭繘浜嗚偪鐦ょ粏鑳炵殑渚佃銆侱u鍚81瀵166浣嶄钩鑵虹檶鎮h呰繘琛屽崟鍥犵礌鍒嗘瀽鍚庤涓篣锛嶱A楂樿〃杈捐匘FS銆丱 S鏄庢樉涓嬮檷銆侳oekcns[9銆戠爺绌朵簡700鍚嶄钩鑵虹檶鎮h呭彂鐜帮紝U锛嶱A闃虫х巼鍦ㄤ钩鑵虹檶鎮h呬腑瑕佹槑鏄鹃珮浜庢甯镐汉缇ゃ侻 ahabel eshw arIl o銆戦氳繃杞煋閲庣敓鍨婼yk鐨凪 DA锛嶮 B锛231涔宠吅鐧岀粏鑳烇紝鑰屼娇閰皑閰哥7閰稿寲IKBa(i nhi bi tors ofN F锛嶬 BQ )鏉ユ姂鍒禢 F锛嶬 B鐨勬椿鎬э紝杩涜屾樉钁楁姂鍒秛锛嶱A鐨勫垎娉屻備粬杩樺Syl 銆愰槼鎬ц〃杈剧殑M CF锛 澶嶆棪澶у涓村簥鍖诲涓冨勾鍒剁澹浣嶈鏂7鍜岄槾鎬ц〃杈剧殑M DA锛嶮 B锛231涓ょ涔宠吅鐧岀粏鑳炴牚鐨勮縼绉讳綔瀵规瘮锛屽彂鐜拌繃琛ㄨ揪閲庣敓鍨婼yk鑳芥姂鍒禡 DA锛嶮 B锛231缁嗚優杩佺Щ锛氳屽皢Syk鐗瑰紓鐨勫弽涔夊鏍歌嫹閰歌浆鏌撳叆M CF-7缁嗚優锛岃兘澶уぇ澧炲姞鍏剁粏鑳炶縼绉婚熷害銆傝繖鏄剧ずSyk鏈夋姂鍒惰偪鐦ょ粏鑳炶縼绉荤殑浣滅敤銆俆akada涔熻繛缁姤绂忓缓蹇笁鎶宸 鈥旈椤-浜嗗湪H 202鍜孴N F璇卞鐨凬 F锛嶬 B淇″彿閫斿緞鐨勬縺娲昏繃绋嬩腑锛孲yk鍙戞尌浜嗗叧閿綔鐢ㄣ11銆戙12銆戙侴RO 鏄竴绉嶄笌鐢熼暱璋冭妭鍜岀値鐥囨湁鍏崇殑缁嗚優鍥犲瓙锛孡i [13銆戝彂鐜癎RO 鐨勮〃杈句笌Syk鐨勮〃杈炬槸璐熺浉鍏崇殑銆侻 DA锛嶮 B锛231 cel l s@ 杩囧害琛ㄨ揪Syk瀵艰嚧浜咷RO tt and-' t鐨勪笅闄嶃侻 CF7cel l s@ 涓嬭皟syk鍙互澧炲姏J ]GRO 鐨勫垎娉屻傚熀璐ㄨ兌涓殑鑲跨槫渚佃鎬ф祴瀹氭彁绀篠yk鐨勮〃杈句笌GRO 鐨勬椿鎬у湪鑲跨槫渚佃鎬у彲鑳界殑鑱旂郴銆傝繘涓姝ョ爺绌惰〃鏄庯紝鍦∕ DAM B锛231缁嗚優涓紝Syk琛ㄨ揪姘村钩涓嶨RO 娲绘у憟璐熺浉鍏炽傛彁绀篏RO 鍙兘鍦⊿yk鐨勬姉鑲跨槫渚佃娲绘х殑浣滅敤涓捣鍒板獟浠嬩綔鐢ㄣ係yk鎶慡J J N F锛嶬 B鐨勬椿鎬э紝鎶戝埗浜哢 锛嶱A鐨勫垎娉岋紝鎶慡J J GRO 鐨勫垎娉屽強娲绘с傝繖琛ㄦ槑Syk鍙兘鏄氳繃鎶戝埗鑲跨槫鍥犲瓙鐨勫垎娉岃揪鍒版姂鍒惰偪鐦ょ粏鑳炵殑鐢熼暱鐨勭洰鐨勩侶 er-2锛弉eu鏄〃鐨敓闀垮洜瀛愬彈浣撳鏃忔垚鍛樹箣涓锛屽畾浣嶄簬鏌撹壊浣17q21锛屾槸鍏鐨勭檶鍩哄洜銆侶 er-2铔嬬櫧鍦ㄦ甯哥殑涔宠吅缁嗚優( 鐢氳嚦涓嶅吀鍨嬪鐢) 涓湴琛ㄨ揪锛岃屽湪20锛-30锛呯殑涔宠吅鐧屼腑鍙繃搴﹁〃杈俱14l 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